Structural and mechanistic basis of the mammalian Nudt12 RNA deNADding

We recently demonstrated mammalian cells harbor NAD-capped mRNAs that are hydrolyzed by the DXO deNADding enzyme. Here we report the Nudix protein Nudt12 is a second mammalian deNADding enzyme structurally and mechanistically distinct from DXO and targeting different RNAs. Crystal structure of mouse...

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Detalles Bibliográficos
Autores principales: Grudzien-Nogalska, Ewa, Wu, Yixuan, Jiao, Xinfu, Cui, Huijuan, Mateyak, Maria K., Hart, Ronald P., Tong, Liang, Kiledjian, Megerditch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527130/
https://www.ncbi.nlm.nih.gov/pubmed/31101919
http://dx.doi.org/10.1038/s41589-019-0293-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527130/
https://www.ncbi.nlm.nih.gov/pubmed/31101919
http://dx.doi.org/10.1038/s41589-019-0293-7

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