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Multi-stage models for the failure of complex systems, cascading disasters, and the onset of disease
Complex systems can fail through different routes, often progressing through a series of (rate-limiting) steps and modified by environmental exposures. The onset of disease, cancer in particular, is no different. Multi-stage models provide a simple but very general mathematical framework for studyin...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527192/ https://www.ncbi.nlm.nih.gov/pubmed/31107895 http://dx.doi.org/10.1371/journal.pone.0216422 |