Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models

Baloxavir marboxil (BXM) is an orally available small molecule inhibitor of cap-dependent endonuclease (CEN), an essential enzyme in the initiation of mRNA synthesis of influenza viruses. In the present study, we evaluated the efficacy of BXM against influenza virus infection in mouse models. Single...

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Detalles Bibliográficos
Autores principales: Fukao, Keita, Ando, Yoshinori, Noshi, Takeshi, Kitano, Mitsutaka, Noda, Takahiro, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527232/
https://www.ncbi.nlm.nih.gov/pubmed/31107922
http://dx.doi.org/10.1371/journal.pone.0217307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527232/
https://www.ncbi.nlm.nih.gov/pubmed/31107922
http://dx.doi.org/10.1371/journal.pone.0217307

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