Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature

Redox stress is a major hallmark of cancer. Analysis of thousands of sequenced cancer exomes and whole genomes revealed distinct mutational signatures that can be attributed to specific sources of DNA lesions. Clustered mutations discovered in several cancer genomes were linked to single-strand DNA...

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Detalles Bibliográficos
Autores principales: Degtyareva, Natalya P., Saini, Natalie, Sterling, Joan F., Placentra, Victoria C., Klimczak, Leszek J., Gordenin, Dmitry A., Doetsch, Paul W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527239/
https://www.ncbi.nlm.nih.gov/pubmed/31067233
http://dx.doi.org/10.1371/journal.pbio.3000263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527239/
https://www.ncbi.nlm.nih.gov/pubmed/31067233
http://dx.doi.org/10.1371/journal.pbio.3000263

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