Cargando…

Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature

Redox stress is a major hallmark of cancer. Analysis of thousands of sequenced cancer exomes and whole genomes revealed distinct mutational signatures that can be attributed to specific sources of DNA lesions. Clustered mutations discovered in several cancer genomes were linked to single-strand DNA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Degtyareva, Natalya P., Saini, Natalie, Sterling, Joan F., Placentra, Victoria C., Klimczak, Leszek J., Gordenin, Dmitry A., Doetsch, Paul W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527239/ https://www.ncbi.nlm.nih.gov/pubmed/31067233 http://dx.doi.org/10.1371/journal.pbio.3000263

Ejemplares similares

Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines
por: Degtyareva, Natalya P., et al.
Publicado: (2013)

Hypermutation in single-stranded DNA
por: Saini, Natalie, et al.
Publicado: (2020)

Hypermutability of Damaged Single-Strand DNA Formed at Double-Strand Breaks and Uncapped Telomeres in Yeast Saccharomyces cerevisiae
por: Yang, Yong, et al.
Publicado: (2008)

Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases
por: Sui, Yang, et al.
Publicado: (2020)

Base Damage within Single-Strand DNA Underlies In Vivo Hypermutability Induced by a Ubiquitous Environmental Agent
por: Chan, Kin, et al.
Publicado: (2012)

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers
por: Chan, Kin, et al.
Publicado: (2015)

Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation
por: Sakofsky, Cynthia J., et al.
Publicado: (2019)

Correction: Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation
por: Sakofsky, Cynthia J., et al.
Publicado: (2020)

Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic
por: Klimczak, Leszek J., et al.
Publicado: (2020)

UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin
por: Saini, Natalie, et al.
Publicado: (2021)

Acetaldehyde makes a distinct mutation signature in single-stranded DNA
por: Vijayraghavan, Sriram, et al.
Publicado: (2022)

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions
por: Marullo, Rossella, et al.
Publicado: (2013)

Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis
por: Ma, Wenjian, et al.
Publicado: (2008)

Yeast require redox switching in DNA primase
por: O’Brien, Elizabeth, et al.
Publicado: (2018)

Strand displacement synthesis by yeast DNA polymerase ε
por: Ganai, Rais A., et al.
Publicado: (2016)

Regulation of base excision repair: Ntg1 nuclear and mitochondrial dynamic localization in response to genotoxic stress
por: Swartzlander, Dan B., et al.
Publicado: (2010)

Yeast Pif1 Accelerates Annealing of Complementary DNA Strands
por: Ramanagoudr-Bhojappa, Ramanagouda, et al.
Publicado: (2014)

Evidence for Retromutagenesis as a Mechanism for Adaptive Mutation in Escherichia coli
por: Morreall, Jordan, et al.
Publicado: (2015)

The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA
por: Fry, Rebecca C, et al.
Publicado: (2006)

Managing Single-Stranded DNA during Replication Stress in Fission Yeast
por: Sabatinos, Sarah A., et al.
Publicado: (2015)

The DNA-Binding Domain of Yeast Rap1 Interacts with Double-Stranded DNA in Multiple Binding Modes
por: Feldmann, Erik A., et al.
Publicado: (2014)

The Double-Stranded DNA Virosphere as a Modular Hierarchical Network of Gene Sharing
por: Iranzo, Jaime, et al.
Publicado: (2016)

Mutational signature distribution varies with DNA replication timing and strand asymmetry
por: Tomkova, Marketa, et al.
Publicado: (2018)

The Chromatin Landscape around DNA Double-Strand Breaks in Yeast and Its Influence on DNA Repair Pathway Choice
por: Frigerio, Chiara, et al.
Publicado: (2023)

Copy number variations of genes involved in stress responses reflect the redox state and DNA damage in brewing yeasts
por: Adamczyk, Jagoda, et al.
Publicado: (2016)

Psychostimulants influence oxidative stress and redox signatures: the role of DNA methylation
por: Sundar, Vaishnavi, et al.
Publicado: (2022)

Cohesin Is Limiting for the Suppression of DNA Damage–Induced Recombination between Homologous Chromosomes
por: Covo, Shay, et al.
Publicado: (2010)

Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication
por: Feng, Wenyi, et al.
Publicado: (2006)

Regulation of yeast DNA polymerase δ-mediated strand displacement synthesis by 5′-flaps
por: Koc, Katrina N., et al.
Publicado: (2015)

Evolution of double-stranded DNA viruses of eukaryotes: from bacteriophages to transposons to giant viruses
por: Koonin, Eugene V, et al.
Publicado: (2015)

The [4Fe4S] Cluster of Yeast DNA Polymerase ε Is Redox Active and Can Undergo DNA-Mediated Signaling
por: Pinto, Miguel N., et al.
Publicado: (2021)

Towards quantitative viromics for both double-stranded and single-stranded DNA viruses
por: Roux, Simon, et al.
Publicado: (2016)

Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease
por: Ma, Wenjian, et al.
Publicado: (2011)

Protected DNA strand displacement for enhanced single nucleotide discrimination in double-stranded DNA
por: Khodakov, Dmitriy A., et al.
Publicado: (2015)

Genetic Evidence for Roles of Yeast Mitotic Cyclins at Single-Stranded Gaps Created by DNA Replication
por: Signon, Laurence
Publicado: (2017)

Mathematical model of chromosomal dynamics during DNA double strand break repair in budding yeast
por: Nakahata, Shinjiro, et al.
Publicado: (2022)

Epigenomic signatures associated with spontaneous and replication stress-induced DNA double strand breaks
por: Kodali, Sravan, et al.
Publicado: (2022)

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis
por: Maciejowski, John, et al.
Publicado: (2020)

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair
por: Abdou, Ismail, et al.
Publicado: (2015)

Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation
por: Xie, Maohua, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_8mbr1eh69h4mqlj56e0ua7v38g