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Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei
BACKGROUND: Toll-like receptors (TLRs) are sentinel receptors of the innate immune system. TLR4 detects bacterial lipopolysaccharide (LPS) and TLR5 detects bacterial flagellin. A common human nonsense polymorphism, TLR5:c.1174C>T, results in a non-functional TLR5 protein. Individuals carrying thi...
Autores principales: | Dickey, Amy K., Chantratita, Narisara, Tandhavanant, Sarunporn, Ducken, Deirdre, Lovelace-Macon, Lara, Seal, Sudeshna, Robertson, Johanna, Myers, Nicolle D., Schwarz, Sandra, Wurfel, Mark M., Kosamo, Susanna, West, T. Eoin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527242/ https://www.ncbi.nlm.nih.gov/pubmed/31067234 http://dx.doi.org/10.1371/journal.pntd.0007354 |
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