Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody

Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells. The transcription factor forkhead box p3 (Foxp3) play...

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Detalles Bibliográficos
Autores principales: Dao, Tao, Mun, Sung Soo, Scott, Andrew C., Jarvis, Casey A., Korontsvit, Tatyana, Yang, Zhiyuan, Liu, Lianxing, Klatt, Martin G., Guerreiro, Manuel, Selvakumar, Annamalai, Brea, Elliott J., Oh, Claire, Liu, Cheng, Scheinberg, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527296/
https://www.ncbi.nlm.nih.gov/pubmed/31143508
http://dx.doi.org/10.1080/2162402X.2019.1570778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527296/
https://www.ncbi.nlm.nih.gov/pubmed/31143508
http://dx.doi.org/10.1080/2162402X.2019.1570778

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