Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression

Nitric oxide (NO) stimulates soluble guanylyl cyclase (sGC) activity, leading to elevated intracellular cyclic guanosine 3′,5′-monophosphate (cGMP) and subsequent vascular smooth muscle relaxation. It is known that downregulation of sGC expression attenuates vascular dilation and contributes to the...

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Detalles Bibliográficos
Autores principales: Galley, Joseph C., Durgin, Brittany G., Miller, Megan P., Hahn, Scott A., Yuan, Shuai, Wood, Katherine C., Straub, Adam C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527398/
https://www.ncbi.nlm.nih.gov/pubmed/30988014
http://dx.doi.org/10.1124/mol.118.115386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527398/
https://www.ncbi.nlm.nih.gov/pubmed/30988014
http://dx.doi.org/10.1124/mol.118.115386

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