LNK suppresses interferon signaling in melanoma

LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway. Elevated LNK en...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Ling-Wen, Sun, Qiao-Yang, Edwards, Jarem J., Fernández, Lucia Torres, Ran, Xue-Bin, Zhou, Si-Qin, Scolyer, Richard A., Wilmott, James S., Thompson, John F., Doan, Ngan, Said, Jonathan W., Venkatachalam, Nachiyappan, Xiao, Jin-Fen, Loh, Xin-Yi, Pein, Maren, Xu, Liang, Mullins, David W., Yang, Henry, Lin, De-Chen, Koeffler, H. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527565/
https://www.ncbi.nlm.nih.gov/pubmed/31110180
http://dx.doi.org/10.1038/s41467-019-09711-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527565/
https://www.ncbi.nlm.nih.gov/pubmed/31110180
http://dx.doi.org/10.1038/s41467-019-09711-y

Ejemplares similares