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Local membrane charge regulates β(2) adrenergic receptor coupling to G(i3)
The β(2) adrenergic receptor (β(2)AR) signals through both G(s) and G(i) in cardiac myocytes, and the G(i) pathway counteracts the G(s) pathway. However, G(i) coupling is much less efficient than G(s) coupling in most cell-based and biochemical assays, making it difficult to study β(2)AR−G(i) intera...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527575/ https://www.ncbi.nlm.nih.gov/pubmed/31110175 http://dx.doi.org/10.1038/s41467-019-10108-0 |