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Local membrane charge regulates β(2) adrenergic receptor coupling to G(i3)

The β(2) adrenergic receptor (β(2)AR) signals through both G(s) and G(i) in cardiac myocytes, and the G(i) pathway counteracts the G(s) pathway. However, G(i) coupling is much less efficient than G(s) coupling in most cell-based and biochemical assays, making it difficult to study β(2)AR−G(i) intera...

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Detalles Bibliográficos
Autores principales:	Strohman, M. J., Maeda, S., Hilger, D., Masureel, M., Du, Y., Kobilka, B. K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527575/ https://www.ncbi.nlm.nih.gov/pubmed/31110175 http://dx.doi.org/10.1038/s41467-019-10108-0

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