Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins

There is still no successful strategy to treat Huntington’s disease, an inherited autosomal disorder associated with the aggregation of mutated forms of the huntingtin protein containing polyglutamine tracts with more than 36 repeats. Recent experimental evidence is challenging the conventional view...

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Detalles Bibliográficos
Autores principales: Bonfanti, Silvia, Lionetti, Maria Chiara, Fumagalli, Maria Rita, Chirasani, Venkat R., Tiana, Guido, Dokholyan, Nikolay V., Zapperi, Stefano, La Porta, Caterina A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527588/
https://www.ncbi.nlm.nih.gov/pubmed/31110208
http://dx.doi.org/10.1038/s41598-019-44151-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527588/
https://www.ncbi.nlm.nih.gov/pubmed/31110208
http://dx.doi.org/10.1038/s41598-019-44151-0

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