Genotype–covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

The genomics era has brought useful tools to dissect the genetic architecture of complex traits. Here we propose a multivariate reaction norm model (MRNM) to tackle genotype–covariate (G–C) correlation and interaction problems. We apply MRNM to the UK Biobank data in analysis of body mass index usin...

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Detalles Bibliográficos
Autores principales: Ni, Guiyan, van der Werf, Julius, Zhou, Xuan, Hyppönen, Elina, Wray, Naomi R., Lee, S. Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527612/
https://www.ncbi.nlm.nih.gov/pubmed/31110177
http://dx.doi.org/10.1038/s41467-019-10128-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527612/
https://www.ncbi.nlm.nih.gov/pubmed/31110177
http://dx.doi.org/10.1038/s41467-019-10128-w

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