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Genotype–covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model
The genomics era has brought useful tools to dissect the genetic architecture of complex traits. Here we propose a multivariate reaction norm model (MRNM) to tackle genotype–covariate (G–C) correlation and interaction problems. We apply MRNM to the UK Biobank data in analysis of body mass index usin...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527612/ https://www.ncbi.nlm.nih.gov/pubmed/31110177 http://dx.doi.org/10.1038/s41467-019-10128-w |