Engineering Synthetic Chromosomes by Sequential Loading of Multiple Genomic Payloads over 100 Kilobase Pairs in Size

Gene delivery vehicles currently in the clinic for treatment of monogenic disorders lack sufficient carrying capacity to efficiently address complex polygenic diseases. Thus, to engineer multifaceted genetic circuits for bioengineering human cells as a therapeutic option for polygenic diseases, we r...

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Detalles Bibliográficos
Autores principales: Greene, Amy, Pascarelli, Kara, Broccoli, Dominique, Perkins, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527818/
https://www.ncbi.nlm.nih.gov/pubmed/31193384
http://dx.doi.org/10.1016/j.omtm.2019.04.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527818/
https://www.ncbi.nlm.nih.gov/pubmed/31193384
http://dx.doi.org/10.1016/j.omtm.2019.04.006

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