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Genome analysis and pleiotropy assessment using causal networks with loss of function mutation and metabolomics
BACKGROUND: Many genome-wide association studies have detected genomic regions associated with traits, yet understanding the functional causes of association often remains elusive. Utilizing systems approaches and focusing on intermediate molecular phenotypes might facilitate biologic understanding....
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528192/ https://www.ncbi.nlm.nih.gov/pubmed/31113383 http://dx.doi.org/10.1186/s12864-019-5772-4 |