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Translation of upstream open reading frames in a model of neuronal differentiation

BACKGROUND: Upstream open reading frames (uORFs) initiate translation within mRNA 5′ leaders, and have the potential to alter main coding sequence (CDS) translation on transcripts in which they reside. Ribosome profiling (RP) studies suggest that translating ribosomes are pervasive within 5′ leaders...

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Detalles Bibliográficos
Autores principales: Rodriguez, Caitlin M., Chun, Sang Y., Mills, Ryan E., Todd, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528255/
https://www.ncbi.nlm.nih.gov/pubmed/31109297
http://dx.doi.org/10.1186/s12864-019-5775-1