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R-spondin2 promotes hematopoietic differentiation of human pluripotent stem cells by activating TGF beta signaling

BACKGROUND: Human pluripotent stem cells (hPSCs) provide supplies of potential functional blood cells to suffice the clinical needs. However, the underlying mechanism of generating genuine hematopoietic stem cells (HSCs) and functional blood cells from hPSCs remains largely elusive. METHOD: In this...

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Detalles Bibliográficos
Autores principales: Wang, Yv, Gao, Jie, Wang, Hongtao, Wang, Mengge, Wen, Yuqi, Guo, Jiaojiao, Su, Pei, Shi, Lihong, Zhou, Wen, Zhou, Jiaxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528258/
https://www.ncbi.nlm.nih.gov/pubmed/31109354
http://dx.doi.org/10.1186/s13287-019-1242-9