High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site

BACKGROUND: Focal Adhesion Kinase (FAK) is a major cancer drug target that is involved in numerous aspects of tumor progression and survival. While multiple research groups have developed ATP-competitive small molecule inhibitors that target the kinase enzyme, recent attention has been focused on th...

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Detalles Bibliográficos
Autores principales: Marlowe, Timothy, Dementiev, Alexey, Figel, Sheila, Rivera, Andrew, Flavin, Michael, Cance, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528292/
https://www.ncbi.nlm.nih.gov/pubmed/31109284
http://dx.doi.org/10.1186/s12860-019-0193-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528292/
https://www.ncbi.nlm.nih.gov/pubmed/31109284
http://dx.doi.org/10.1186/s12860-019-0193-4

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