Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture

BACKGROUND: Repeated culture reduces within-sample Mycobacterium tuberculosis genetic diversity due to selection of clones suited to growth in culture and/or random loss of lineages, but it is not known to what extent omitting the culture step altogether alters genetic diversity. We compared M. tube...

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Detalles Bibliográficos
Autores principales: Nimmo, Camus, Shaw, Liam P., Doyle, Rona, Williams, Rachel, Brien, Kayleen, Burgess, Carrie, Breuer, Judith, Balloux, Francois, Pym, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528373/
https://www.ncbi.nlm.nih.gov/pubmed/31109296
http://dx.doi.org/10.1186/s12864-019-5782-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528373/
https://www.ncbi.nlm.nih.gov/pubmed/31109296
http://dx.doi.org/10.1186/s12864-019-5782-2

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