The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility

OBJECTIVE: To examine the effect of pSer9-GSK-3β on breast cancer and to determine whether the underlying metabolic and immunological mechanism is associated with ROS/eIF2B and natural killer (NK) cells. METHODS: We employed TWS119 to inactivate GSK-3β by phosphorylating Ser9 and explored its effect...

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Detalles Bibliográficos
Autores principales: Jin, Fengjiao, Wu, Zhaozhen, Hu, Xiao, Zhang, Jiahui, Gao, Zihe, Han, Xiao, Qin, Junfang, Li, Chen, Wang, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Anti-Cancer Association 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528454/
https://www.ncbi.nlm.nih.gov/pubmed/31119045
http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528454/
https://www.ncbi.nlm.nih.gov/pubmed/31119045
http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0253

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