Inhibition of immune checkpoints PD-1, CTLA-4, and IDO1 coordinately induces immune-mediated liver injury in mice

Cancer cells harness immune checkpoints such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and indoleamine 2,3-dioxygenase 1 (IDO1) to evade immune control. Checkpoint inhibitors have demonstrated durable anti-tumor efficacy in human and preclinical...

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Detalles Bibliográficos
Autores principales: Affolter, Timothy, Llewellyn, Heather P., Bartlett, Derek W., Zong, Qing, Xia, Shuhua, Torti, Vince, Ji, Changhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528985/
https://www.ncbi.nlm.nih.gov/pubmed/31112568
http://dx.doi.org/10.1371/journal.pone.0217276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528985/
https://www.ncbi.nlm.nih.gov/pubmed/31112568
http://dx.doi.org/10.1371/journal.pone.0217276

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