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MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response

When mammalian cells detect a viral infection, they initiate a type I interferon (IFNs) response as part of their innate immune system. This antiviral mechanism is conserved in virtually all cell types, except for embryonic stem cells (ESCs) and oocytes which are intrinsically incapable of producing...

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Detalles Bibliográficos
Autores principales: Witteveldt, Jeroen, Knol, Lisanne I, Macias, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529217/
https://www.ncbi.nlm.nih.gov/pubmed/31012846
http://dx.doi.org/10.7554/eLife.44171