Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

How huntingtin (HTT) triggers neurotoxicity in Huntington’s disease (HD) remains unclear. We report that HTT forms a transcription-coupled DNA repair (TCR) complex with RNA polymerase II subunit A (POLR2A), ataxin-3, the DNA repair enzyme polynucleotide-kinase-3'-phosphatase (PNKP), and cyclic...

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Detalles Bibliográficos
Autores principales: Gao, Rui, Chakraborty, Anirban, Geater, Charlene, Pradhan, Subrata, Gordon, Kara L, Snowden, Jeffrey, Yuan, Subo, Dickey, Audrey S, Choudhary, Sanjeev, Ashizawa, Tetsuo, Ellerby, Lisa M, La Spada, Albert R, Thompson, Leslie M, Hazra, Tapas K, Sarkar, Partha S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529219/
https://www.ncbi.nlm.nih.gov/pubmed/30994454
http://dx.doi.org/10.7554/eLife.42988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529219/
https://www.ncbi.nlm.nih.gov/pubmed/30994454
http://dx.doi.org/10.7554/eLife.42988

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