Challenge model of TNF(α) turnover at varying LPS and drug provocations

A mechanism-based biomarker model of TNF(α)-response, including different external provocations of LPS challenge and test compound intervention, was developed. The model contained system properties (such as k(t), k(out)), challenge characteristics (such as k(s), k(LPS), K(m, LPS), S(max), SC(50)) an...

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Detalles Bibliográficos
Autores principales: Held, Felix, Hoppe, Edmund, Cvijovic, Marija, Jirstrand, Mats, Gabrielsson, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529397/
https://www.ncbi.nlm.nih.gov/pubmed/30778719
http://dx.doi.org/10.1007/s10928-019-09622-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529397/
https://www.ncbi.nlm.nih.gov/pubmed/30778719
http://dx.doi.org/10.1007/s10928-019-09622-x

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