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Challenge model of TNF(α) turnover at varying LPS and drug provocations
A mechanism-based biomarker model of TNF(α)-response, including different external provocations of LPS challenge and test compound intervention, was developed. The model contained system properties (such as k(t), k(out)), challenge characteristics (such as k(s), k(LPS), K(m, LPS), S(max), SC(50)) an...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529397/ https://www.ncbi.nlm.nih.gov/pubmed/30778719 http://dx.doi.org/10.1007/s10928-019-09622-x |