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Ciliary and cytoskeletal functions of an ancient monooxygenase essential for bioactive amidated peptide synthesis
Many secreted peptides used for cell–cell communication require conversion of a C-terminal glycine to an amide for bioactivity. This reaction is catalyzed only by the integral membrane protein peptidylglycine α-amidating monooxygenase (PAM). PAM has been highly conserved and is found throughout the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529398/ https://www.ncbi.nlm.nih.gov/pubmed/30879092 http://dx.doi.org/10.1007/s00018-019-03065-w |