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The extracellular gate shapes the energy profile of an ABC exporter
ABC exporters harness the energy of ATP to pump substrates across membranes. Extracellular gate opening and closure are key steps of the transport cycle, but the underlying mechanism is poorly understood. Here, we generated a synthetic single domain antibody (sybody) that recognizes the heterodimeri...
Autores principales: | Hutter, Cedric A. J., Timachi, M. Hadi, Hürlimann, Lea M., Zimmermann, Iwan, Egloff, Pascal, Göddeke, Hendrik, Kucher, Svetlana, Štefanić, Saša, Karttunen, Mikko, Schäfer, Lars V., Bordignon, Enrica, Seeger, Markus A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529423/ https://www.ncbi.nlm.nih.gov/pubmed/31113958 http://dx.doi.org/10.1038/s41467-019-09892-6 |
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