Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031

Gemcitabine is a fluoropyrimidine analogue that is used as a mainstay of chemotherapy treatment for pancreatic and ovarian cancers, amongst others. Despite its widespread use, gemcitabine achieves responses in less than 10% of patients with metastatic pancreatic cancer and has a very limited impact...

Descripción completa

Detalles Bibliográficos
Autores principales: Sarr, Awa, Bré, Jennifer, Um, In Hwa, Chan, Tsz Huen, Mullen, Peter, Harrison, David J., Reynolds, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529431/
https://www.ncbi.nlm.nih.gov/pubmed/31113993
http://dx.doi.org/10.1038/s41598-019-44089-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529431/
https://www.ncbi.nlm.nih.gov/pubmed/31113993
http://dx.doi.org/10.1038/s41598-019-44089-3

Ejemplares similares