XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis

XPO1 (exportin1) mediates nuclear export of proteins and RNAs and is frequently overexpressed in cancers. In this study, we show that the orally bioavailable XPO1 inhibitor KPT-330 reduced Mcl-1 protein level, by which it synergized with Bcl-xL inhibitor A-1331852 to induce apoptosis in cancer cells...

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Detalles Bibliográficos
Autores principales: Zhu, Zhi-Chuan, Liu, Ji-Wei, Yang, Can, Zhao, Miao, Xiong, Zhi-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529444/
https://www.ncbi.nlm.nih.gov/pubmed/31113936
http://dx.doi.org/10.1038/s41419-019-1627-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529444/
https://www.ncbi.nlm.nih.gov/pubmed/31113936
http://dx.doi.org/10.1038/s41419-019-1627-9

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