Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the enzyme cGAS may act anti-inflammatory. Here we repor...

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Detalles Bibliográficos
Autores principales: Lama, Lodoe, Adura, Carolina, Xie, Wei, Tomita, Daisuke, Kamei, Taku, Kuryavyi, Vitaly, Gogakos, Tasos, Steinberg, Joshua I., Miller, Michael, Ramos-Espiritu, Lavoisier, Asano, Yasutomi, Hashizume, Shogo, Aida, Jumpei, Imaeda, Toshihiro, Okamoto, Rei, Jennings, Andy J., Michino, Mayako, Kuroita, Takanobu, Stamford, Andrew, Gao, Pu, Meinke, Peter, Glickman, J. Fraser, Patel, Dinshaw J., Tuschl, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529454/
https://www.ncbi.nlm.nih.gov/pubmed/31113940
http://dx.doi.org/10.1038/s41467-019-08620-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529454/
https://www.ncbi.nlm.nih.gov/pubmed/31113940
http://dx.doi.org/10.1038/s41467-019-08620-4

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