Diverse MR1-restricted T cells in mice and humans

Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like molecule, MR1. Whether MAIT cell development depends on this invariant TCR-α chain is unclear. Here we generate Traj33-deficient mice and show that they are highly depleted...

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Detalles Bibliográficos
Autores principales: Koay, Hui-Fern, Gherardin, Nicholas A., Xu, Calvin, Seneviratna, Rebecca, Zhao, Zhe, Chen, Zhenjun, Fairlie, David P., McCluskey, James, Pellicci, Daniel G., Uldrich, Adam P., Godfrey, Dale I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529461/
https://www.ncbi.nlm.nih.gov/pubmed/31113973
http://dx.doi.org/10.1038/s41467-019-10198-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529461/
https://www.ncbi.nlm.nih.gov/pubmed/31113973
http://dx.doi.org/10.1038/s41467-019-10198-w

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