Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation

Osteoarthritis (OA) results from an imbalance of the dynamic equilibrium between the breakdown and repair of joint tissues. Previously, we reported that Runx1 enhanced chondrogenic differentiation through transcriptional induction of COL2A1, and suppressed hypertrophic differentiation. Here, we inve...

Descripción completa

Detalles Bibliográficos
Autores principales: Yano, Fumiko, Ohba, Shinsuke, Murahashi, Yasutaka, Tanaka, Sakae, Saito, Taku, Chung, Ung-il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529519/
https://www.ncbi.nlm.nih.gov/pubmed/31113964
http://dx.doi.org/10.1038/s41598-019-43948-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529519/
https://www.ncbi.nlm.nih.gov/pubmed/31113964
http://dx.doi.org/10.1038/s41598-019-43948-3

Ejemplares similares