Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms

Epigenetic control of enhancers alters neuronal functions and may be involved in Alzheimer’s disease (AD). Here, we identify enhancers in neurons contributing to AD by comprehensive fine-mapping of DNA methylation at enhancers, genome-wide. We examine 1.2 million CpG and CpH sites in enhancers in pr...

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Detalles Bibliográficos
Autores principales: Li, Peipei, Marshall, Lee, Oh, Gabriel, Jakubowski, Jennifer L., Groot, Daniel, He, Yu, Wang, Ting, Petronis, Arturas, Labrie, Viviane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529540/
https://www.ncbi.nlm.nih.gov/pubmed/31113950
http://dx.doi.org/10.1038/s41467-019-10101-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529540/
https://www.ncbi.nlm.nih.gov/pubmed/31113950
http://dx.doi.org/10.1038/s41467-019-10101-7

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