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Maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly

Maslinic acid, derived from olive fruit, reduces pro-inflammation cytokines, which are involved in muscle fiber atrophy. Therefore, the maslinic acid ingestion may enhance the muscular response to resistance training through anti-inflammatory action. We therefore conducted a parallel, double-blind,...

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Autores principales: Nagai, Narumi, Yagyu, Satomi, Hata, Anna, Nirengi, Shinsuke, Kotani, Kazuhiko, Moritani, Toshio, Sakane, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529705/
https://www.ncbi.nlm.nih.gov/pubmed/31138956
http://dx.doi.org/10.3164/jcbn.18-104
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author Nagai, Narumi
Yagyu, Satomi
Hata, Anna
Nirengi, Shinsuke
Kotani, Kazuhiko
Moritani, Toshio
Sakane, Naoki
author_facet Nagai, Narumi
Yagyu, Satomi
Hata, Anna
Nirengi, Shinsuke
Kotani, Kazuhiko
Moritani, Toshio
Sakane, Naoki
author_sort Nagai, Narumi
collection PubMed
description Maslinic acid, derived from olive fruit, reduces pro-inflammation cytokines, which are involved in muscle fiber atrophy. Therefore, the maslinic acid ingestion may enhance the muscular response to resistance training through anti-inflammatory action. We therefore conducted a parallel, double-blind, randomized, placebo-controlled trial that examined whether a combination of maslinic acid supplementation and resistance training improve mobility functions in community-dwelling elderly persons. Over a 12-week period, 36 participants underwent moderate resistance training and are assigned to the maslinic acid supplementation (n = 17, 60 mg/day) or the placebo (n = 19) group. At baseline and at 12-weeks, we assessed body composition, grip strength, walking speed, leg strength, mobility functions, and knee pain scores. Following the 12-weeks, skeletal muscle mass, segmental muscle mass (right arm, left arm, and trunk) and knee pain score of the right leg were significantly improved in the maslinic acid group, while there was no change or parameters had worsened in the placebo group. Grip strength of the better side significantly increased only in the maslinic acid group. These results suggest that maslinic acid supplementation combined with moderate resistance training may increase upper muscle mass and grip strength, and reduce knee pain, could be effective for preventing mobility-related disability in elderly persons. Clinical trial registration number: UMIN000017207.
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spelling pubmed-65297052019-05-28 Maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly Nagai, Narumi Yagyu, Satomi Hata, Anna Nirengi, Shinsuke Kotani, Kazuhiko Moritani, Toshio Sakane, Naoki J Clin Biochem Nutr Original Article Maslinic acid, derived from olive fruit, reduces pro-inflammation cytokines, which are involved in muscle fiber atrophy. Therefore, the maslinic acid ingestion may enhance the muscular response to resistance training through anti-inflammatory action. We therefore conducted a parallel, double-blind, randomized, placebo-controlled trial that examined whether a combination of maslinic acid supplementation and resistance training improve mobility functions in community-dwelling elderly persons. Over a 12-week period, 36 participants underwent moderate resistance training and are assigned to the maslinic acid supplementation (n = 17, 60 mg/day) or the placebo (n = 19) group. At baseline and at 12-weeks, we assessed body composition, grip strength, walking speed, leg strength, mobility functions, and knee pain scores. Following the 12-weeks, skeletal muscle mass, segmental muscle mass (right arm, left arm, and trunk) and knee pain score of the right leg were significantly improved in the maslinic acid group, while there was no change or parameters had worsened in the placebo group. Grip strength of the better side significantly increased only in the maslinic acid group. These results suggest that maslinic acid supplementation combined with moderate resistance training may increase upper muscle mass and grip strength, and reduce knee pain, could be effective for preventing mobility-related disability in elderly persons. Clinical trial registration number: UMIN000017207. the Society for Free Radical Research Japan 2019-05 2019-03-07 /pmc/articles/PMC6529705/ /pubmed/31138956 http://dx.doi.org/10.3164/jcbn.18-104 Text en Copyright © 2019 JCBN http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nagai, Narumi
Yagyu, Satomi
Hata, Anna
Nirengi, Shinsuke
Kotani, Kazuhiko
Moritani, Toshio
Sakane, Naoki
Maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly
title Maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly
title_full Maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly
title_fullStr Maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly
title_full_unstemmed Maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly
title_short Maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly
title_sort maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529705/
https://www.ncbi.nlm.nih.gov/pubmed/31138956
http://dx.doi.org/10.3164/jcbn.18-104
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