Cargando…

Rack1 mediates tyrosine phosphorylation of Anxa2 by Src and promotes invasion and metastasis in drug-resistant breast cancer cells

BACKGROUND: Acquirement of resistance is always associated with a highly aggressive phenotype of tumor cells. Recent studies have revealed that Annexin A2 (Anxa2) is a key protein that links drug resistance and cancer metastasis. A high level of Anxa2 in cancer tissues is correlated to a highly aggr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Yanling, Si, Weiyao, Ji, Wei, Wang, Zhiyong, Gao, Zicong, Tian, Ran, Song, Weijie, Zhang, He, Niu, Ruifang, Zhang, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530024/ https://www.ncbi.nlm.nih.gov/pubmed/31113450 http://dx.doi.org/10.1186/s13058-019-1147-7

Ejemplares similares

Rack1 mediates Src binding to drug transporter P-glycoprotein and modulates its activity through regulating Caveolin-1 phosphorylation in breast cancer cells
por: Fan, Yanling, et al.
Publicado: (2019)

Rack1 Mediates the Interaction of P-Glycoprotein with Anxa2 and Regulates Migration and Invasion of Multidrug-Resistant Breast Cancer Cells
por: Yang, Yi, et al.
Publicado: (2016)

Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast cancer cells
por: Wang, Tong, et al.
Publicado: (2015)

Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanism
por: Wang, Tong, et al.
Publicado: (2019)

RACK1 interaction with c-Src is essential for osteoclast function
por: Park, Jin Hee, et al.
Publicado: (2019)

Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
por: Scales, Timothy ME, et al.
Publicado: (2011)

Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src
por: Irtegun, Sevgi, et al.
Publicado: (2013)

c‐Cbl Is Inducibly Tyrosine‐phosphorylated by Epidermal Growth Factor Stimulation in Fibroblasts, and Constitutively Tyrosine‐phosphorylated and Associated with v‐Src in v‐src‐transformed Fibroblasts
por: Odai, Hideharu, et al.
Publicado: (1995)

SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stability via the PI3K/AKT/GSK3β signaling pathway
por: Yuan, Yue, et al.
Publicado: (2020)

RACK1 facilitates breast cancer progression by competitively inhibiting the binding of β-catenin to PSMD2 and enhancing the stability of β-catenin
por: Tian, Ruinan, et al.
Publicado: (2023)

Drug-resistant cancer cell-derived exosomal EphA2 promotes breast cancer metastasis via the EphA2-Ephrin A1 reverse signaling
por: Gao, Zicong, et al.
Publicado: (2021)

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis
por: Zhang, Jia, et al.
Publicado: (2017)

Tyrosine Phosphorylation and Src Family Kinases Control Keratinocyte Cell–Cell Adhesion
por: Calautti, Enzo, et al.
Publicado: (1998)

Src Kinase Phosphorylates RUNX3 at Tyrosine Residues and Localizes the Protein in the Cytoplasm
por: Goh, Yun-Mi, et al.
Publicado: (2010)

Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases
por: Fernow, Inga, et al.
Publicado: (2009)

Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphase
por: Chu, Ching-Tung, et al.
Publicado: (2021)

Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle
por: Morii, Mariko, et al.
Publicado: (2021)

Src-Dependent NM2A Tyrosine Phosphorylation Regulates Actomyosin Remodeling
por: Brito, Cláudia, et al.
Publicado: (2023)

Elevated STAT3 Signaling-Mediated Upregulation of MMP-2/9 Confers Enhanced Invasion Ability in Multidrug-Resistant Breast Cancer Cells
por: Zhang, Fei, et al.
Publicado: (2015)

Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis
por: Wang, Hsueh-Chun, et al.
Publicado: (2014)

Tyrosine Phosphorylation Based Homo-dimerization of Arabidopsis RACK1A Proteins Regulates Oxidative Stress Signaling Pathways in Yeast
por: Sabila, Mercy, et al.
Publicado: (2016)

Src-Mediated Phosphorylation of the Tyrosine Phosphatase PRL-3 Is Required for PRL-3 Promotion of Rho Activation, Motility and Invasion
por: Fiordalisi, James J., et al.
Publicado: (2013)

The Overexpression of Scaffolding Protein NEDD9 Promotes Migration and Invasion in Cervical Cancer via Tyrosine Phosphorylated FAK and SRC
por: Sima, Ni, et al.
Publicado: (2013)

FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer
por: Long, Yufei, et al.
Publicado: (2022)

EphA2–YES1–ANXA2 pathway promotes gastric cancer progression and metastasis
por: Mao, Linfeng, et al.
Publicado: (2021)

Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases
por: Liu, Yuanbo, et al.
Publicado: (2010)

The Role of Hypoxia and SRC Tyrosine Kinase in Glioblastoma Invasiveness and Radioresistance
por: Torrisi, Filippo, et al.
Publicado: (2020)

Tubulin is phosphorylated at tyrosine by pp60c-src in nerve growth cone membranes
Publicado: (1990)

Drosophila Kelch regulates actin organization via Src64-dependent tyrosine phosphorylation
por: Kelso, Reed J., et al.
Publicado: (2002)

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility
por: Wang, Wenqi, et al.
Publicado: (2011)

Endocytosis of somatodendritic NCKX2 is regulated by Src family kinase-dependent tyrosine phosphorylation
por: Lee, Kyu-Hee, et al.
Publicado: (2013)

Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and SHP-2 Recruitment
por: Stefanski, Adrianne L., et al.
Publicado: (2022)

Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells
por: Mak, Hannah, et al.
Publicado: (2012)

TGF‐β transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways
por: Zhao, Yuanyuan, et al.
Publicado: (2018)

Cul4A Modulates Invasion and Metastasis of Lung Cancer through Regulation of ANXA10
por: Hung, Ming-Szu, et al.
Publicado: (2019)

Correction to: EphA2–YES1–ANXA2 pathway promotes gastric cancer progression and metastasis
por: Mao, Linfeng, et al.
Publicado: (2022)

Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer
por: Tian, Qin, et al.
Publicado: (2020)

EF24 Suppresses Invasion and Migration of Hepatocellular Carcinoma Cells In Vitro via Inhibiting the Phosphorylation of Src
por: Zhao, Ran, et al.
Publicado: (2016)

Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation
por: Jin, Yue, et al.
Publicado: (2016)

Inhibition of ANXA2 activity attenuates epileptic susceptibility and GluA1 phosphorylation
por: Ma, Limin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_p8m649sdpa0133ak0dg5dr1gaq