Complement 3(+)-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

Astrogliosis and activation of microglia are hallmarks of prion diseases in humans and animals. Both were viewed to be rather independent events in disease pathophysiology, with proinflammatory microglia considered to be the potential neurotoxic species at late disease stages. Recent investigations...

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Detalles Bibliográficos
Autores principales: Hartmann, Kristin, Sepulveda-Falla, Diego, Rose, Indigo V. L., Madore, Charlotte, Muth, Christiane, Matschke, Jakob, Butovsky, Oleg, Liddelow, Shane, Glatzel, Markus, Krasemann, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530067/
https://www.ncbi.nlm.nih.gov/pubmed/31118110
http://dx.doi.org/10.1186/s40478-019-0735-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530067/
https://www.ncbi.nlm.nih.gov/pubmed/31118110
http://dx.doi.org/10.1186/s40478-019-0735-1

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