Cargando…

N-n-Butyl Haloperidol Iodide Ameliorates Oxidative Stress in Mitochondria Induced by Hypoxia/Reoxygenation through the Mitochondrial c-Jun N-Terminal Kinase/Sab/Src/Reactive Oxygen Species Pathway in H9c2 Cells

Both c-Jun N-terminal kinase (JNK) and reactive oxygen species (ROS) play important roles in myocardial ischemia/reperfusion (I/R) injury. Our previous studies suggest that N-n-butyl haloperidol iodide (F(2)) exerts cardioprotection by reducing ROS production and JNK activation caused by I/R. In thi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chu, Qianwen, Zhang, Yanmei, Zhong, Shuping, Gao, Fenfei, Chen, Yicun, Wang, Bin, Zhang, Zhaojing, Cai, Wenfeng, Li, Weiqiu, Zheng, Fuchun, Shi, Ganggang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530120/ https://www.ncbi.nlm.nih.gov/pubmed/31205589 http://dx.doi.org/10.1155/2019/7417561

Ejemplares similares

N-n-Butyl Haloperidol Iodide, a Derivative of the Anti-psychotic Haloperidol, Antagonizes Hypoxia/Reoxygenation Injury by Inhibiting an Egr-1/ROS Positive Feedback Loop in H9c2 Cells
por: Sun, Ting, et al.
Publicado: (2018)

N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy
por: Wang, Bin, et al.
Publicado: (2015)

N-n-butyl Haloperidol Iodide Protects against Hypoxia/Reoxygenation Injury in Cardiac Microvascular Endothelial Cells by Regulating the ROS/MAPK/Egr-1 Pathway
por: Lu, Shishi, et al.
Publicado: (2017)

N-n-Butyl Haloperidol Iodide Ameliorates Cardiomyocytes Hypoxia/Reoxygenation Injury by Extracellular Calcium-Dependent and -Independent Mechanisms
por: Zhang, Yanmei, et al.
Publicado: (2013)

Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation
por: Zhang, Yanmei, et al.
Publicado: (2015)

N-n-butyl haloperidol iodide ameliorates hypoxia/reoxygenation injury through modulating the LKB1/AMPK/ROS pathway in cardiac microvascular endothelial cells
por: Lu, Binger, et al.
Publicado: (2016)

Design, Synthesis, and Pharmacological Evaluation of Haloperidol Derivatives as Novel Potent Calcium Channel Blockers with Vasodilator Activity
por: Chen, Yicun, et al.
Publicado: (2011)

N-n-butyl haloperidol iodide inhibits H(2)O(2)-induced Na(+)/Ca(2+)-exchanger activation via the Na(+)/H(+) exchanger in rat ventricular myocytes
por: Huang, Yong-Pan, et al.
Publicado: (2014)

Self-Assembled Nanoparticles of Glycyrrhetic Acid-Modified Pullulan as a Novel Carrier of Curcumin
por: Yuan, Roufen, et al.
Publicado: (2014)

Synergistic Effect of Compounds from a Chinese Herb: Compatibility and Dose Optimization of Compounds from N-Butanol Extract of Ipomoea stolonifera
por: Cai, Congyi, et al.
Publicado: (2016)

c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1
por: Tian, Xiaodong, et al.
Publicado: (2021)

N,N′,N′′-Tricyclohexylguanidinium iodide
por: Said, Farouq F., et al.
Publicado: (2011)

Optimized Extraction of Polysaccharides from Grateloupia livida (Harv.) Yamada and Biological Activities
por: Ye, Danyan, et al.
Publicado: (2015)

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases
por: Guma, Monica, et al.
Publicado: (2012)

Sab
por: Gómez de Avellaneda y Arteaga, Gertrudis, 1814-1873
Publicado: (1976)

Quaternary tryptammonium salts: N,N-dimethyl-N-n-propyltryptammonium (DMPT) iodide and N-allyl-N,N-dimethyltryptammonium (DMALT) iodide
por: Chadeayne, Andrew R., et al.
Publicado: (2020)

Anti-Inflammatory Activity of N-Butanol Extract from Ipomoea stolonifera In Vivo and In Vitro
por: Cai, Congyi, et al.
Publicado: (2014)

Di-n-butylbis(N-n-butyl-N-ethyldithiocarbamato-κS)tin(IV)
por: Baba, Ibrahim, et al.
Publicado: (2009)

Sab : novela
por: Gómez de Avellaneda y Arteaga, Gertrudis, 1814-1873
Publicado: (1970)

C‐Jun N‐terminal kinase signalling pathway in response to cisplatin
por: Yan, Dong, et al.
Publicado: (2016)

Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase
por: Biggi, Silvia, et al.
Publicado: (2017)

Inhibitors of c-Jun N-terminal kinases—JuNK no more?
por: Bogoyevitch, Marie A., et al.
Publicado: (2008)

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
por: Anfinogenova, Nina D., et al.
Publicado: (2020)

c-Jun N-Terminal Kinase Signaling Inhibitors Under Development
por: Han, Sun-Young
Publicado: (2008)

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
por: Chen, Jing, et al.
Publicado: (2021)

N,N,N-Tributylbutan-1-aminium (T-4)-(cyano-κC)trihydroborate
por: Maris, Thierry
Publicado: (2013)

Sab : novela original
por: Gómez de Avellaneda y Arteaga, Gertrudis, 1814-1873
Publicado: (1963)

4-Ethoxycarbonyl-N,N,N-trimethylanilinium iodide
por: Tang, Xiao-Yan
Publicado: (2011)

Stressor-Like Effects of c-Jun N-Terminal Kinase (JNK) Inhibition
por: Clarke, Melanie, et al.
Publicado: (2012)

c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity
por: Muñoz-Alonso, María J., et al.
Publicado: (2013)

C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy
por: Klein, SR, et al.
Publicado: (2015)

Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis
por: Mitomo, S., et al.
Publicado: (2016)

Resveratrol, novel application by preconditioning to attenuate myocardial ischemia/reperfusion injury in mice through regulate AMPK pathway and autophagy level
por: Li, Haiyan, et al.
Publicado: (2022)

Protective effect of black garlic extracts on tert-Butyl hydroperoxide-induced injury in hepatocytes via a c-Jun N-terminal kinase-dependent mechanism
por: Lee, Ko-Chao, et al.
Publicado: (2018)

Knockout of phospholipase Cε attenuates N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder tumorigenesis
por: JIANG, TAIMAO, et al.
Publicado: (2016)

Trichlorido(N,N′-di-tert-butylbenzamidinato-κ(2) N,N′)silicon
por: Lv, Lu-Dan, et al.
Publicado: (2008)

Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase
por: Marcus, David J., et al.
Publicado: (2015)

c-Jun N-Terminal Kinases (JNKs) in Myocardial and Cerebral Ischemia/Reperfusion Injury
por: Shvedova, Maria, et al.
Publicado: (2018)

C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes
por: Duong, Men Thi Hoai, et al.
Publicado: (2020)

c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis
por: Bagnoud, Maud, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_e0sie3aeiv3pnrng5fb0nvo3tt