Abnormal Thyroid Hormone Status Differentially Affects Bone Mass Accrual and Bone Strength in C3H/HeJ Mice: A Mouse Model of Type I Deiodinase Deficiency

C3H/HeJ (C3H) mice are deficient of type I deiodinase (D1), an enzyme that activates thyroid hormone (TH), converting thyroxine (T4) to triiodothyronine (T3). Nevertheless, C3H mice present normal serum T3 and a gross euthyroid phenotype. To investigate if a global D1 deficiency interferes in the TH...

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Detalles Bibliográficos
Autores principales: Zaitune, Clarissa R., Fonseca, Tatiana L., Capelo, Luciane P., Freitas, Fatima R., Beber, Eduardo H., Dora, José M., Wang, Charles C., Miranda-Rodrigues, Manuela, Nonaka, Keico O., Maia, Ana L., Gouveia, Cecilia H. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530334/
https://www.ncbi.nlm.nih.gov/pubmed/31156551
http://dx.doi.org/10.3389/fendo.2019.00300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530334/
https://www.ncbi.nlm.nih.gov/pubmed/31156551
http://dx.doi.org/10.3389/fendo.2019.00300

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