Impact of a patient-derived hepatitis C viral RNA genome with a mutated microRNA binding site

Hepatitis C virus (HCV) depends on liver-specific microRNA miR-122 for efficient viral RNA amplification in liver cells. This microRNA interacts with two different conserved sites at the very 5’ end of the viral RNA, enhancing miR-122 stability and promoting replication of the viral RNA. Treatment o...

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Detalles Bibliográficos
Autores principales: Mata, Miguel, Neben, Steven, Majzoub, Karim, Carette, Jan, Ramanathan, Muthukumar, Khavari, Paul A., Sarnow, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530871/
https://www.ncbi.nlm.nih.gov/pubmed/31075158
http://dx.doi.org/10.1371/journal.ppat.1007467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530871/
https://www.ncbi.nlm.nih.gov/pubmed/31075158
http://dx.doi.org/10.1371/journal.ppat.1007467

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