(CTG)n repeat-mediated dysregulation of MBNL1 and MBNL2 expression during myogenesis in DM1 occurs already at the myoblast stage

Myotonic dystrophy type 1 (DM1) is a severe neuromuscular disorder caused by the expression of trinucleotide repeat-containing DMPK transcripts. Abnormally expanded (CUG)n repeats in these transcripts form hairpin-like structures that cause the RNA to accumulate in the cell nucleus by sequestering i...

Descripción completa

Detalles Bibliográficos
Autores principales: André, Laurène M., van Cruchten, Remco T. P., Willemse, Marieke, Wansink, Derick G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530876/
https://www.ncbi.nlm.nih.gov/pubmed/31116797
http://dx.doi.org/10.1371/journal.pone.0217317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530876/
https://www.ncbi.nlm.nih.gov/pubmed/31116797
http://dx.doi.org/10.1371/journal.pone.0217317

Ejemplares similares