PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy

No current treatment targets cardiac proteotoxicity or can reduce mortality of heart failure (HF) with preserved ejection fraction (HFpEF). Selective degradation of misfolded proteins by the ubiquitin-proteasome system (UPS) is vital to the cell. Proteasome impairment contributes to HF. Activation o...

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Detalles Bibliográficos
Autores principales: Zhang, Hanming, Pan, Bo, Wu, Penglong, Parajuli, Nirmal, Rekhter, Mark D., Goldberg, Alfred L., Wang, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531002/
https://www.ncbi.nlm.nih.gov/pubmed/31131329
http://dx.doi.org/10.1126/sciadv.aaw5870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531002/
https://www.ncbi.nlm.nih.gov/pubmed/31131329
http://dx.doi.org/10.1126/sciadv.aaw5870

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