Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms

In recent years, evidence has accumulated to suggest that mutant huntingtin protein (mHTT) can spread into healthy tissue in a prion-like fashion. This theory, however, remains controversial. To fully address this concept and to understand the possible consequences of mHTT spreading to Huntington’s...

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Detalles Bibliográficos
Autores principales: Masnata, Maria, Sciacca, Giacomo, Maxan, Alexander, Bousset, Luc, Denis, Hélèna L., Lauruol, Florian, David, Linda, Saint-Pierre, Martine, Kordower, Jeffrey H., Melki, Ronald, Alpaugh, Melanie, Cicchetti, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531424/
https://www.ncbi.nlm.nih.gov/pubmed/30788585
http://dx.doi.org/10.1007/s00401-019-01973-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531424/
https://www.ncbi.nlm.nih.gov/pubmed/30788585
http://dx.doi.org/10.1007/s00401-019-01973-6

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