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Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms
In recent years, evidence has accumulated to suggest that mutant huntingtin protein (mHTT) can spread into healthy tissue in a prion-like fashion. This theory, however, remains controversial. To fully address this concept and to understand the possible consequences of mHTT spreading to Huntington’s...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531424/ https://www.ncbi.nlm.nih.gov/pubmed/30788585 http://dx.doi.org/10.1007/s00401-019-01973-6 |