Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity

Both α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been implicated in the pathology of Parkinson’s disease (PD). Although studies suggest that αSyn and its missense mutant, A53T, preferentially accumulate in the mitochondria, the mechanisms by which αSyn and mitochondrial protei...

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Detalles Bibliográficos
Autores principales: Hu, Di, Sun, Xiaoyan, Liao, Xudong, Zhang, Xinwen, Zarabi, Sara, Schimmer, Aaron, Hong, Yuning, Ford, Christopher, Luo, Yu, Qi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531426/
https://www.ncbi.nlm.nih.gov/pubmed/30877431
http://dx.doi.org/10.1007/s00401-019-01993-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531426/
https://www.ncbi.nlm.nih.gov/pubmed/30877431
http://dx.doi.org/10.1007/s00401-019-01993-2

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