The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices

Membrane ruffling and lamellipodia formation promote the motility of adherent cells in two-dimensional motility assays by mechano-sensing of the microenvironment and initiation of focal adhesions towards their surroundings. Lamellipodium formation is stimulated by small Rho GTPases of the Rac subfam...

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Detalles Bibliográficos
Autores principales: Kunschmann, Tom, Puder, Stefanie, Fischer, Tony, Steffen, Anika, Rottner, Klemens, Mierke, Claudia Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531482/
https://www.ncbi.nlm.nih.gov/pubmed/31118438
http://dx.doi.org/10.1038/s41598-019-43975-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531482/
https://www.ncbi.nlm.nih.gov/pubmed/31118438
http://dx.doi.org/10.1038/s41598-019-43975-0

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