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Histidine‐rich glycoprotein augments natural killer cell function by modulating PD‐1 expression via CLEC‐1B

Augmentation of natural killer (NK) cell cytotoxicity is one of the greatest challenges for cancer immunotherapy. Although histidine‐rich glycoprotein (HRG), a 75‐kDa glycoprotein with various immunomodulatory activities, reportedly elicits antitumor immunity, its effect on NK cell cytotoxicity is u...

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Detalles Bibliográficos
Autores principales: Nishimura, Yoshito, Wake, Hidenori, Teshigawara, Kiyoshi, Wang, Dengli, Sakaguchi, Masakiyo, Otsuka, Fumio, Nishibori, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531599/
https://www.ncbi.nlm.nih.gov/pubmed/31143450
http://dx.doi.org/10.1002/prp2.481