A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death

SARM1, an NAD-utilizing enzyme, regulates axonal degeneration. We show that CZ-48, a cell-permeant mimetic of NMN, activated SARM1 in vitro and in cellulo to cyclize NAD and produce a Ca(2+) messenger, cADPR, with similar efficiency as NMN. Knockout of NMN-adenylyltransferase elevated cellular NMN a...

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Detalles Bibliográficos
Autores principales: Zhao, Zhi Ying, Xie, Xu Jie, Li, Wan Hua, Liu, Jun, Chen, Zhe, Zhang, Ben, Li, Ting, Li, Song Lu, Lu, Jun Gang, Zhang, Liangren, Zhang, Li-he, Xu, Zhengshuang, Lee, Hon Cheung, Zhao, Yong Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531917/
https://www.ncbi.nlm.nih.gov/pubmed/31128467
http://dx.doi.org/10.1016/j.isci.2019.05.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531917/
https://www.ncbi.nlm.nih.gov/pubmed/31128467
http://dx.doi.org/10.1016/j.isci.2019.05.001

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