Cargando…

A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death

SARM1, an NAD-utilizing enzyme, regulates axonal degeneration. We show that CZ-48, a cell-permeant mimetic of NMN, activated SARM1 in vitro and in cellulo to cyclize NAD and produce a Ca(2+) messenger, cADPR, with similar efficiency as NMN. Knockout of NMN-adenylyltransferase elevated cellular NMN a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Zhi Ying, Xie, Xu Jie, Li, Wan Hua, Liu, Jun, Chen, Zhe, Zhang, Ben, Li, Ting, Li, Song Lu, Lu, Jun Gang, Zhang, Liangren, Zhang, Li-he, Xu, Zhengshuang, Lee, Hon Cheung, Zhao, Yong Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531917/ https://www.ncbi.nlm.nih.gov/pubmed/31128467 http://dx.doi.org/10.1016/j.isci.2019.05.001

Ejemplares similares

A Novel Fluorescent Cell Membrane-permeable Caged Cyclic ADP-ribose Analogue
por: Yu, Pei-Lin, et al.
Publicado: (2012)

Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate
por: Li, Wan Hua, et al.
Publicado: (2021)

A Cell Permeable NPE Caged ADP-Ribose for Studying TRPM2
por: Yu, Peilin, et al.
Publicado: (2012)

The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila
por: Llobet Rosell, Arnau, et al.
Publicado: (2022)

Vascular physiology of a Ca(2+) mobilizing second messenger - cyclic ADP - ribose
por: Zhang, Andrew Y, et al.
Publicado: (2006)

Pancreatic β-Cell Death, Regeneration and Insulin Secretion: Roles of Poly(ADP-Ribose) Polymerase and Cyclic ADP-Ribose
por: Takasawa, Shin, et al.
Publicado: (2002)

Molecular Bases of Catalysis and ADP-Ribose Preference of Human Mn(2+)-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase and Conversion by Mutagenesis to a Preferential Cyclic ADP-Ribose Phosphohydrolase
por: Cabezas, Alicia, et al.
Publicado: (2015)

Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase
por: Ribeiro, João Meireles, et al.
Publicado: (2018)

‘Click cyclic ADP-ribose’: a neutral second messenger mimic
por: Swarbrick, Joanna M., et al.
Publicado: (2014)

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist
por: Kirchberger, Tanja, et al.
Publicado: (2009)

Cyclic ADP ribose is a novel regulator of intracellular Ca(2+) oscillations in human bone marrow mesenchymal stem cells
por: Tao, Rong, et al.
Publicado: (2011)

Altered CD38/Cyclic ADP-Ribose Signaling Contributes to the Asthmatic Phenotype
por: Jude, Joseph A., et al.
Publicado: (2012)

CD38–Cyclic ADP-Ribose Signal System in Physiology, Biochemistry, and Pathophysiology
por: Takasawa, Shin
Publicado: (2022)

Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
por: Nadeeshani, Harshani, et al.
Publicado: (2021)

Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38
por: Swarbrick, Joanna M., et al.
Publicado: (2014)

Influence of Permeant Ions on Gating in Cyclic Nucleotide–gated Channels
por: Holmgren, Miguel
Publicado: (2003)

Design and Synthesis of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose, a Calcium Ion-Mobilizing Second Messenger**
por: Tsuzuki, Takayoshi, et al.
Publicado: (2013)

Oncogenic activity of poly (ADP-ribose) glycohydrolase
por: Marques, Maud, et al.
Publicado: (2018)

Characterization of Two NMN Deamidase Mutants as Possible Probes for an NMN Biosensor
por: Camarca, Alessandra, et al.
Publicado: (2021)

TCDD-inducible Poly (ADP-ribose) Polymerase Promotes Adipogenesis of Both Brown and White Preadipocytes
por: Liu, Lingchao, et al.
Publicado: (2022)

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes
por: Gagné, Jean-Philippe, et al.
Publicado: (2008)

Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
por: Wang, Cheng, et al.
Publicado: (2019)

Inhibition of CD38/Cyclic ADP-ribose Pathway Protects Rats against Ropivacaine-induced Convulsion
por: Zou, Yu, et al.
Publicado: (2017)

Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?
por: Fliegert, Ralf, et al.
Publicado: (2020)

Downregulation of the Cd38-Cyclic ADP-Ribose Signaling in Cardiomyocytes by Intermittent Hypoxia via Pten Upregulation
por: Takasawa, Shin, et al.
Publicado: (2022)

Update on Poly ADP-Ribose Polymerase Inhibitors in Ovarian Cancer With Non-BRCA Mutations
por: Xu, Qin, et al.
Publicado: (2021)

Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice
por: Zhong, Jing, et al.
Publicado: (2016)

β-Cyanuryl Ribose, β-Barbituryl Ribose, and 6-Azauridine as Uridine Mimetics
por: Salameh, Helaneh, et al.
Publicado: (2020)

Telomerase and poly(ADP-ribose) polymerase-1 activity sensing based on the high fluorescence selectivity and sensitivity of TOTO-1 towards G bases in single-stranded DNA and poly(ADP-ribose)
por: Yang, Haitang, et al.
Publicado: (2019)

Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool
por: Li, Yang, et al.
Publicado: (2021)

Permeant Ion-Dependent Changes in Gating of Kir2.1 Inward Rectifier Potassium Channels
por: Lu, Tao, et al.
Publicado: (2001)

Poly(ADP-ribose): An organizer of cellular architecture
por: Leung, Anthony K.L.
Publicado: (2014)

Poly (ADP-ribose) in the pathogenesis of Parkinson's disease
por: Lee, Yunjong, et al.
Publicado: (2014)

RNA regulation by Poly(ADP-ribose) polymerases
por: Bock, Florian J., et al.
Publicado: (2015)

Mitotic functions of poly(ADP-ribose) polymerases
por: Slade, Dea
Publicado: (2019)

The Antiviral Activities of Poly-ADP-Ribose Polymerases
por: Malgras, Mathilde, et al.
Publicado: (2021)

ARH Family of ADP-Ribose-Acceptor Hydrolases
por: Ishiwata-Endo, Hiroko, et al.
Publicado: (2022)

Crystallographic and Biochemical Analysis of the Mouse Poly(ADP-Ribose) Glycohydrolase
por: Wang, Zhizhi, et al.
Publicado: (2014)

The NMN Module Conducts Nodule Number Orchestra
por: Wang, Zhijuan, et al.
Publicado: (2020)

Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers
por: Tesauro, Cinzia, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5kkbfkhcdnb8lsq54sdjblj9m4