Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides

BACKGROUND: Targeting epitopes derived from neo-antigens (or “neo-epitopes”) represents a promising immunotherapy approach with limited off-target effects. However, most peptides predicted using MHC binding prediction algorithms do not induce a CD8 + T cell response, and there is a crucial need to r...

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Detalles Bibliográficos
Autores principales: Besser, Hanan, Yunger, Sharon, Merhavi-Shoham, Efrat, Cohen, Cyrille J., Louzoun, Yoram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532181/
https://www.ncbi.nlm.nih.gov/pubmed/31118084
http://dx.doi.org/10.1186/s40425-019-0595-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532181/
https://www.ncbi.nlm.nih.gov/pubmed/31118084
http://dx.doi.org/10.1186/s40425-019-0595-z

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